time, you need to test enough samples to find those few. Making
decisions on positive results from performance of only a few
samples assumes a greater level of risk.
It’s also fair to say that the usual safety testing done on personal care products—patch testing and preservative effectiveness
testing—is a bare minimum for establishing the overall integrity
of a product.
BR: The main challenges for clients is the different worldwide
testing requirements and an uncertain regulatory environment in
Happi: Has your company invested in new equipment/space/
services for household or personal care testing? Please tell us
about those enhancements.
JT: Princeton Consumer Research has invested in our 11,000 sq.
ft., state-of-the-art global headquarters in Princeton, NJ. This
site has one of the largest environmentally controlled rooms in
the US, a full service hair salon, and a wide array of the latest
Our newest 12,000 sq. ft. site in St. Petersburg, FL is opening
in November, and will offer the same amount of bio-instrumen-tation as well as two large environmentally-controlled rooms.
PY: This year again we invested in the development of our capabilities in terms of instrumentation on one side, this is the
case for the extreme weather conditions room for specific clinical tests (e.g. antiperspirant for extreme sports), or analytical
instruments for in vitro tests such as KeratinoSens and DPRA
(sensitization), but also in terms of new clinical centers in order
to address the growing demand for clinical and solar testing;
i.e., Bangkok, Thailand; Jakarta, Indonesia and more recently,
in Lille, France.
• The US Environmental Protection Agency (EPA) and Unilever announced a research collaboration to develop ground-breaking scientific
approaches to better assess the safety of chemicals found in some
consumer products without using animal data.
The alternative and cutting-edge approaches, which ePA and
Unilever are developing, represent the first steps in a paradigm shift
for chemical safety testing and risk assessment by making
them faster, cheaper and more relevant to humans.
These new tools will provide a robust scientific basis for assessing and managing chemical safety
and efficiently quantifying human health risks for
thousands of chemicals.
ePA and Unilever will develop a series of
case studies based on chemicals of mutual
interest. ePA will develop and provide data
using these automated chemical screening
technologies. Unilever will use its longstanding
expertise in consumer products to estimate exposures for the chemicals. Together, the ePA and
Unilever will work to combine the information into a
risk assessment. The collaboration will help inform how
ePA’s Toxcast project can be used by private and public entities as well as in the development of chemical risk assessments.
Unilever is contributing more than $800,000 and considerable scientific expertise to help generate and integrate new exposure data to
develop a model approach for high throughput risk assessments that
include both hazard and exposure predictions. The Unilever initiative
comes from its safety and environmental Assurance centre which, as it
celebrates its 25th year of existence in 2015, sees this research area of
non-animal approaches as being one of the enduring “big scientific challenges” that has shaped its evolution during the past 25 years (www.
The collaboration will use data from ePA’s Toxcast program and the
affiliated Tox21 consortium, which is a collaboration among ePA, the
national institutes of Health (niH) and the Food and Drug Administration
(FDA). These programs use automated chemical screening technologies to rapidly and efficiently test thousands of chemicals for their effects on human cells or cellular components that are critical to normal
function. Data from these technologies are then incorporated into computational models to predict potential
adverse health effects and estimate the amount of
chemical that may cause these effects.
The new collaboration aims to incorporate
elements that have been previously missing
from the automated chemical screening approach such as tools for incorporating metabolism of the test chemicals and a more
comprehensive evaluation of the human
biological pathways that can be affected.
Unilever, in providing a statement to Happi,
commented: “since the 1980s, Unilever’s
leading-edge science has focused on developing new non-animal approaches that can guarantee
that our products are safe, without any need for animal testing. These principles have also been at the heart of ground-breaking
computational toxicology research led by the ePA to generate data on
thousands of chemicals and figuring how this new data can help assess the safety of chemicals. Through this collaboration, Unilever and
ePA will bring together ePA’s new chemical data and Unilever’s understanding of how consumers are exposed to ingredients in products to
determine if these new approaches can be used to more effectively and
efficiently assess chemicals. We anticipate that both wider industry and
government will benefit from the use of these advanced tools and non-animal based approaches.”
EPA AND UNILEvER SEARCH FOR ANIMAL TEST ALTERNATIVES