values that would be found in skin roughly 20 years younger. Notably,
the subjects in the age group 56-65 displayed skin roughness that
would be expected in subjects of 35. 4 years. This corresponds to rejuvenating the roughness by 28. 5 years within only 28 days (Figure 4).
Dry skin is a breeding ground for premature aging and eventually
contributes to altered smoothness, elasticity and firmness. Hydrated
skin, in contrast, is properly functional, looks smooth and young,
and tends toward retarded skin aging. External moisturizers can be
helpful. However, it is not just a matter of supplying the skin with
additional moisture, but also of storing and retaining the moisture
as long as possible.
Hydractin-LMF perfectly meets this requirement: Firstly the
abbreviation LMF stands for a combination of extracts from lichen,
moss and fern, which creates an effective moisturizer. Secondly the
suffix LMF is also relates to the NMF; i.e., the sum of a large number
of water-retaining substances whose main task consists of retaining
water in the stratum corneum layer of the skin. Using the active ingredient can help to enrich the substances of the NMF in the upper
layers of the skin, and thus delivers not only an immediate moisturizing effect, but also a moisture-retaining effect.
Taken together, the active ingredient is able to turn back the skin’s
biological clock: after two weeks, the skin becomes approximately 10
years younger. After four weeks it even gained 20 years of youthfulness. Moreover, the active ingredient is also effective when it comes
to foot care: stressed, cornified and cracked feet felt good again and
were perceptibly and visibly soft and delicate (not shown).•
Stefan Bänziger, PhD, Head of R&D Cosmetic Actives, Rahn AG, Dörflistrasse
120, CH-8050 Zürich; Tel: + 41 44 315 42 00; Email: BaenzigerS@rahn-group.com;
1. Manuskiatti W, Schwindt DA, Maibach HI (1998)
Influence of age, anatomic site and race on skin roughness and scaliness. Dermatology 196: 401-407.
2. Engelke M, Jensen JM, Ekanayake-Mudiyanselage S, Proksch E (1997) Effects of xerosis and
ageing on epidermal proliferation and differentiation. Br
J Dermatol 137: 219-225.
3. Hall G, Phillips TJ (2005) Estrogen and skin: the
effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Dermatol 53: 555-
568; quiz 569-572.
4. Wilhelm KP, Cua AB, Maibach HI (1991) Skin
aging. Effect on transepidermal water loss, stratum
corneum hydration, skin surface pH, and casual sebum
content. Arch Dermatol 127: 1806-1809.
5. Cua AB, Wilhelm KP, Maibach HI (1990)
Frictional properties of human skin: relation to age, sex
and anatomical region, stratum corneum hydration and
transepidermal water loss. Br J Dermatol 123: 473-479.
6. Boyer G, Laquieze L, Le Bot A, Laquieze S, Zahouani H (2009) Dynamic indentation on human skin in vivo: aging effects. Skin Res Technol 15: 55-67.
7. Luebberding S, Krueger N, Kerscher M (2013) Age-related changes in skin barrier
function - quantitative evaluation of 150 female subjects. Int J Cosmet Sci 35: 183-190.
8. Man MQ, Xin SJ, Song SP, Cho SY, Zhang XJ, et al. (2009) Variation of skin surface pH, sebum content and stratum corneum hydration with age and gender in a large
Chinese population. Skin Pharmacol Physiol 22: 190-199.
9. Hillebrand GG, Liang Z, Yan X, Yoshii T (2010) New wrinkles on wrinkling: an
8-year longitudinal study on the progression of expression lines into persistent wrinkles.
Br J Dermatol 162: 1233-1241.
10. EMEA (2014) Assessment Report on Cetraria islandica (L.) acharius s.l. , thallus.
Evaluation of Medicines for Human Use
11. Schmidgall J, Schnetz E, Hensel A (2000) Evidence for bioadhesive effects of polysaccharides and polysaccharide-containing herbs in an ex vivo bioadhesion assay on buccal membranes. Planta Med 66: 48-53.
12. Glime JM (2007) Chapter 7-4: Water Relations: Leaf Strategies. Bryophyte Ecology,
Physiological Ecology. pp. 29-40.
13. Saxena DK, Harinder (2004) Uses of Bryophytes. Resonance: 56-65.
14. Podterob AP, Zubets EV (2002) A History of the Medicinal Use of Plants of the
Genus Sphagnum. Pharmaceutical Chemistry Journal 36: 192-194.
15. EMEA (2008) Assessment Report on Polypodium vulgare L., Rhizoma. Evaluation
of Medicines for Human Use
16. Dar PA, Sofi G, Jafri MA (2012) Polypodium Vulgar Linn. A Versatil Herbal
Medicine: A Review. International Journal of Pharmaceutical Sciences and Research 3:
17. Simon A, Vanyolos A, Beni Z, Dekany M, Toth G, et al. (2011) Ecdysteroids from
Polypodium vulgare L. Steroids 76: 1419-1424.
18. Dinan L (2009) The Karlson Lecture. Phytoecdysteroids: what use are they? Arch
Insect Biochem Physiol 72: 126-141.
19. Lafont R, Dinan L (2009) Innovative and Future Applications for Ecdysteroids.
Ecdysone: Structures and Functions Chapter 23: 551-578.
Figure 4: Hydrate the age away. Skin parameters were measured in age group 56-65 years upon application
of the active ingredient for 0, 14 and 28 days. Using the regression line functions (see figure 1), corresponding
ages and hence rejuvenation effects were calculated. Reading example: After 14 and 28 days of application,
the test subjects displayed skin roughness which, on a calculated basis, would be expected in test subjects of
47. 6 and 35. 4 years respectively. This corresponds to a rejuvenating effect of 16. 3 and 28. 5 years within 14 and
28 days. F4/F3: see legend figure 1; RZ: a decrease corresponds to a decrease in the mean depth of roughness.