yet developed moderate to severe
cellulite and may have a family
history of cellulite,” explained
DermaGenoma CEO Andy
Goren. A patient testing positive
for the ACE variant has approximately a 70% chance of developing moderate to severe cellulite.
Lacey, WA-based Unigen, Inc.,
has launched Nivitol, a botanical
anti-aging skin care ingredient.
Unigen has entered into multiple
global license and supply agree-
ments for Nivitol with manufacturers and marketers of skin
care, makeup, fragrance and hair
Nivitol is a natural botanical
alternative, derived from the
novel plant extract Dianella ensi-folia, which has been scientifically
acid) that is found in citrus fruits and dark green leafy
vegetables, plays an essential role in the production of collagen and elastin. Because of its antioxidant properties, vitamin C may reverse the negative effects of UV radiation in
the skin, but there are few clinically controlled studies to
confirm this theory.
“An animal study examining the role of vitamin C in
reversing sun damage found that when 5% ascorbate was
applied two hours before UVB and UVA exposure, UVB-
induced skin wrinkling was reduced,” said Dr. Kim. “Some
of the human clinical trials have shown similar favorable
results when applying a daily dose of L-ascorbic acid treat-
ment, but all of these studies involved small sample sizes.”
In addition, Dr. Kim pointed out that one concern of adding
vitamin C to cosmeceuticals is that vitamin C is unstable when
used in formulations and it is not known how much, if any,
intact molecule remains when applied to the skin.
“This problem has been partially overcome by chemically
modifying ascorbic acid,” said Dr. Kim. “However, for the
body to use the supplied ascorbic acid, it must convert it to
L-ascorbic acid and many of the stabilized, commercially
available forms have not been examined
to determine whether this conversion is possible. For that
reason, the average consumer will not be able to determine
if a cosmeceutical containing vitamin C will be effective.”
Vitamin E: A Primary Antioxidant
Vitamin E, or tocopherol, is a fat-soluble vitamin and its synthetic form is found in many over-the-counter products.
Working as an antioxidant, vitamin E protects cell membranes and is thought to play an important role in skin
aging because of its antioxidant properties. While topical
vitamin E is available in a variety of products, there is no
data that support claims that it improves skin wrinkling, discoloration and texture.
“Topical vitamin E has been studied in humans, as in
mice, more as a protectant to be used before sun exposure
than as an agent to be included in cosmeceuticals to reduce
the signs of skin aging,” said Dr. Kim. “Through research we
have learned that UV exposure significantly decreases levels
of cutaneous vitamin E, and vitamin C should be included in
any formulation containing vitamin E because of the impor-
tant role it plays in maintaining active vitamin E levels.”
Research also has explored combining vitamins E
and C as an oral supplement to provide sun protection.
Multiple studies suggest that this combination therapy is
beneficial for photoprotection.